If you cannot start Epson Scan, try these solutions:
Windows 8.x: Navigate to the Apps screen and select EPSON Scan Settings. Make sure the correct Connection setting is selected, then click the Test button.
Windows (other versions): Click
or
Start > All Programs or Programs > EPSON > EPSON
Scan > EPSON Scan
Settings. Make sure the correct Connection setting is selected, then click the
Test button.
OS X: Open the Applications folder, click Epson Software, and click EPSON Scan Settings. Make sure the correct Connection setting is selected, then click the Test button.