If you cannot start Epson Scan, try these solutions:
Windows 8: Navigate to the Start screen and select EPSON Scan Settings. Make sure the correct Connection setting is selected, then click the Test button.
Windows (other versions): Click or Start > All Programs or Programs > EPSON > EPSON Scan > EPSON Scan Settings. Make sure the correct Connection setting is selected, then click the Test button.
Mac OS X: Open the Applications folder, click Epson Software, and click EPSON Scan Settings. Make sure the correct Connection setting is selected, then click the Test button.